From the Cover: Gene Networks in Development and Evolution Special Feature Sackler Colloquium: Properties of developmental gene regulatory networks
Abstract
The modular components, or subcircuits, of developmental gene regulatory networks (GRNs) execute specific developmental functions, such as the specification of cell identity. We survey examples of such subcircuits and relate their structures to corresponding developmental functions. These relations transcend organisms and genes, as illustrated by the similar structures of the subcircuits controlling the specification of the mesectoderm in the Drosophila embryo and the endomesoderm in the sea urchin, even though the respective subcircuits are composed of nonorthologous regulatory genes.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- December 2008
- DOI:
- 10.1073/pnas.0806007105
- Bibcode:
- 2008PNAS..10520063D
- Keywords:
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- Gene Networks in Development and Evolution Special Feature Sackler Colloquium:Introductory Perspective