Natural Selection Fails to Optimize Mutation Rates for Long-Term Adaptation on Rugged Fitness Landscapes Clune, Jeff ; Misevic, Dusan ; Ofria, Charles ; Lenski, Richard E. ; Elena, Santiago F. ; Sanjuán, Rafael Abstract Publication: PLoS Computational Biology Pub Date: September 2008 DOI: 10.1371/journal.pcbi.1000187 Bibcode: 2008PLSCB...4E0187C