We use a high-resolution nested climate model to investigate future changes in snowmelt-driven runoff (SDR) over the western US. Comparison of modeled and observed daily runoff data reveals that the regional model captures the present-day timing and trends of SDR. Results from an A2 scenario simulation indicate that increases in seasonal temperature of approximately 3° to 5°C resulting from increasing greenhouse gas concentrations could cause SDR to occur as much as two months earlier than present. These large changes result from an amplified snow-albedo feedback driven by the topographic complexity of the region, which is more accurately resolved in a high-resolution nested climate model. Earlier SDR could affect water storage in reservoirs and hydroelectric generation, with serious consequences for land use, agriculture, and water management in the American West.