A substantial fraction of the Edgeworth-Kuiper belt objects are presently known to move in resonance with Neptune (the principal commensurabilities are 1/2, 3/5, 2/3, and 3/4). We have found that many of the distant (with orbital semimajor axes a > 50 AU) trans-Neptunian objects (TNOs) also execute resonant motions. Our investigation is based on symplectic integrations of the equations of motion for all multiple-opposition TNOs with a > 50 AU with allowance made for the uncertainties in their initial orbits. Librations near such commensurabilities with Neptune as 4/9, 3/7, 5/12, 2/5, 3/8, 4/27, and others have been found. The largest number of distant TNOs move near the 2/5 resonance with Neptune: 12 objects librate with a probability higher than 0.75. The multiplicity of objects moving in 2/5 resonance and the longterm stability of their librations suggest that this group of resonant objects was formed at early formation stages of the Solar system. For most of the other resonant objects, the librations are temporary. We also show the importance of asymmetric resonances in the large changes in TNO perihelion distances.