The use of functional genomics for the identification of a gene cluster encoding for the biosynthesis of an antifungal tambjamine in the marine bacterium Pseudoalteromonas tunicata
Abstract
SummaryA large insert library was created in Escherichia coli from the DNA of the surface-associated marine bacterium Pseudoalteromonas tunicata. Screening of the library for antifungal activity resulted in the detection and identification of a large gene cluster encoding for the biosynthesis of an antifungal tambjamine. A biosynthetic pathway has been proposed based on analysis and annotation of the gene cluster.
- Publication:
-
Environmental Microbiology
- Pub Date:
- March 2007
- DOI:
- 10.1111/j.1462-2920.2006.01177.x
- Bibcode:
- 2007EnvMi...9..814B