Double-stranded helical twisted β-sheet channels in crystals of gramicidin S grown in the presence of trifluoroacetic and hydrochloric acids
Abstract
Gramicidin S, a membrane-active antibiotic, was crystallized from solvent containing water, methanol, trifluoroacetic acid and hydrochloric acid. The structure was refined at 0.95 Å resolution and contains 1.5 molecules of gramicidin S, two trifluoracetic acid molecules and ten water molecules in the crystallographic asymmetric unit. In the crystals, the gramicidin S molecules line up into helical channels that differ from those observed previously.
- Publication:
-
Acta Crystallographica Section D
- Pub Date:
- February 2007
- DOI:
- 10.1107/S0907444906056435FILE: /proj/ads/abstracts/
- Bibcode:
- 2007AcCrD..63..401L
- Keywords:
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- gramicidin S;
- antibiotics