Critical Single-Point Mutations and Protein Folding Pathways.
Abstract
Single-point mutations can have a dramatic effect on protein structure. Treating a mutation as a perturbation of a protein's folded structure may not reveal a significant effect on that structure. The dependence of a protein's structure on a mutation may only be understood when the mutation's effect on the folding pathway is known. A united-residue model (Liwo et al., PNAS, 102, 2367, 2005) was used to study the effect of single-point mutations on protein folding pathways. <small>To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2007.NWS07.C1.1</small>
- Publication:
-
APS Northwest Section Meeting Abstracts
- Pub Date:
- May 2007
- Bibcode:
- 2007APS..NWS.C1001C