Long-Term Transmission of Defective RNA Viruses in Humans and Aedes Mosquitoes
Abstract
In 2001, dengue virus type 1 (DENV-1) populations in humans and mosquitoes from Myanmar acquired a stop-codon mutation in the surface envelope (E) protein gene. Within a year, this stop-codon strain had spread to all individuals sampled. The presence of truncated E protein species within individual viral populations, along with a general relaxation in selective constraint, indicated that the stop-codon strain represents a defective lineage of DENV-1. We propose that such long-term transmission of defective RNA viruses in nature was achieved through complementation by coinfection of host cells with functional viruses.
- Publication:
-
Science
- Pub Date:
- January 2006
- DOI:
- 10.1126/science.1115030
- Bibcode:
- 2006Sci...311..236A
- Keywords:
-
- VIROLOGY