KATP channels as molecular sensors of cellular metabolism
Abstract
In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (KATP) channel activity provides a unique link between cellular energetics and electrical excitability. Over the past ten years, a steady drumbeat of crystallographic and electrophysiological studies has led to detailed structural and kinetic models that define the molecular basis of channel activity. In parallel, the uncovering of disease-causing mutations of KATP has led to an explanation of the molecular basis of disease and, in turn, to a better understanding of the structural basis of channel function.
- Publication:
-
Nature
- Pub Date:
- March 2006
- DOI:
- 10.1038/nature04711
- Bibcode:
- 2006Natur.440..470N