Tungsten trioxide microspheres of 2-4 μm diameter have been prepared by controlled oxidation of tungsten carbide microspheres. These microspheres are characterized by XRD, SEM, and HRTEM. The microspheres are made of WO 3 nanoparticles with an average diameter of around 15 nm. Platinum supported on these WO 3 microspheres exhibits higher and stable electrocatalytic activity for methanol oxidation by a factor of around two, than commercial 20 wt.% Pt-Ru/Vulcan-XC72 carbon and 20 wt.% Pt-Ru/carbon microspheres even without Ru. The higher activity is attributed to the better tolerance to carbon monoxide of the Pt/WO 3 catalyst. These Pt/WO 3 microspheres appear to be a promising alternative anode material for direct methanol fuel cells. They replace Ru entirely and save a substantial amount of Pt in the Pt-Ru electrode that is presently employed in fluel cells.