Analgesia Mediated by the TRPM8 Cold Receptor in Chronic Neuropathic Pain
Abstract
Summary. Background. Chronic established pain, especially that following nerve injury, is difficult to treat and represents a largely unmet therapeutic need. New insights are urgently required, and we reasoned that endogenous processes such as cooling-induced analgesia may point the way to novel strategies for intervention. Molecular receptors for cooling have been identified in sensory nerves, and we demonstrate here how activation of one of these, TRPM8, produces profound, mechanistically novel analgesia in chronic pain states.
- Publication:
-
Current Biology
- Pub Date:
- August 2006
- DOI:
- 10.1016/j.cub.2006.07.061
- Bibcode:
- 2006CBio...16.1591P
- Keywords:
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- SYSNEURO