Coupled dynamics of voltage and calcium in paced cardiac cells
Abstract
We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model, and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasiperiodic oscillations of voltage and calcium.
- Publication:
-
Physical Review E
- Pub Date:
- February 2005
- DOI:
- 10.1103/PhysRevE.71.021903
- arXiv:
- arXiv:physics/0405048
- Bibcode:
- 2005PhRvE..71b1903S
- Keywords:
-
- 87.19.Hh;
- 82.40.Bj;
- 05.45.Tp;
- Cardiac dynamics;
- Oscillations chaos and bifurcations;
- Time series analysis;
- Biological Physics