Survival adjustment of mature dendritic cells by IL-15
Abstract
The survival of CD8+/CD44hi memory phenotype T cells depends on an IL-15 activity on nonlymphoid cells. Here, we report that IL-15 and its receptor were induced on dendritic cells (DCs) by a combination of IFN-γ and NF-κB relA inducers. IL-15 conferred in an autocrine loop resistance to apoptosis that accompanied the maturation process in DCs in vitro. As an apparent result in vivo, mice deficient in IL-15 or its receptor harbor few DCs. Injecting DCs into IL-15-/- mice was associated with the appearance of CD8+/CD44hi T cells that depended on IL-15 expression but also correlated with the longevity of the DCs. These findings support the hypothesis that DCs mediate the effect of IL-15 on CD8+/CD44hi memory phenotype T cells.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- June 2005
- DOI:
- 10.1073/pnas.0503360102
- Bibcode:
- 2005PNAS..102.8662D
- Keywords:
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- IMMUNOLOGY