The use of oscillatory signals in the study of genetic networks
Abstract
The structure of a genetic network is uncovered by studying its response to external stimuli (input signals). We present a theory of propagation of an input signal through a linear stochastic genetic network. We found that there are important advantages in using oscillatory signals over step or impulse signals and that the system may enter into a pure fluctuation resonance for a specific input frequency.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- May 2005
- DOI:
- 10.1073/pnas.0403790102
- arXiv:
- arXiv:q-bio/0502033
- Bibcode:
- 2005PNAS..102.7063L
- Keywords:
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- APPLIED PHYSICAL SCIENCES;
- Quantitative Biology - Molecular Networks
- E-Print:
- 46 pages, 5 figures. Submitted to PNAS on May 27th 2004. The paper is under consideration