The deep structures of the Central-Southern Apennines are analysed on the basis of the regional component of gravity anomalies, obtained applying a stripping technique. This procedure allows the accurate removal of the gravimetric effect of the three-dimensional shallow (within the first 10 km) geological bodies from the observed Bouguer anomaly. The resulting anomaly map differs quite significantly from the Bouguer anomaly map, providing new constraints on the nature of the deeper part of the crust and on the upper mantle. The stripping reveals that the regional gravity lows are shifted westward in comparison with Bouguer anomaly lows. Moreover, the gravimetric pattern indicates a lack of cylindrism for the deep structures of the Apennine Chain, which in the study area can be roughly divided into three main segments. The observed differences between the gravity anomalies pattern of the Central Apennines and that of the Southern Apennines are marked. The integration of gravimetric results with other geophysical data suggests that: (i) a ramp-dominated style for the buried Apulia (Adria) units and part of the underlying basement is compatible with gravimetric data and (ii) most of the regional gravity anomalies in the Central Apennines seem to originate within the lower crust.