Active fault zones of Armenia, SE Turkey and NW Iran present a diverse set of interrelated natural hazards. Three regional case studies in this cross-border zone are examined to show how earthquakes interact with other hazards to increase the risk of natural disaster. In northern Armenia, a combination of several natural and man-made phenomena (earthquakes, landslides and unstable dams with toxic wastes) along the Pambak-Sevan-Sunik fault (PSSF) zone lowers from 0.4 to 0.2-0.3 g the maximum permissible level (MPL) of seismic hazard that may induce disastrous destruction and loss of life in the adjacent Vanadzor depression. In the Ararat depression, a large active fault-bounded pull-apart basin at the junction of borders of Armenia, Turkey, Iran and Azerbaijan, an earthquake in 1840 was accompanied by an eruption of Ararat Volcano, lahars, landslides, floods, soil subsidence and liquefaction. The case study demonstrates that natural hazards that are secondary with respect to earthquakes may considerably increase the damage and the casualties and increase the risk associated with the seismic impact. The North Tabriz-Gailatu fault system poses a high seismic hazard to the border areas of NW Iran, eastern Turkey, Nakhichevan (Azerbaijan) and southern Armenia. Right-lateral strike-slip motions along the North Tabriz fault have given rise to strong earthquakes, which threaten the city of Tabriz with its population of 1.2 million. The examples illustrate how the concentration of natural hazards in active fault zones increases the risk associated with strong earthquakes in Armenia, eastern Turkey and NW Iran. This generally occurs across the junctions of international borders. Hence, the transboundary character of active faults requires transboundary cooperation in the study and mitigation of the natural risk.