A model of morphogenesis
Abstract
A new model is presented of a patterning mechanism in animals. It is argued that the ‘Wnt’ signaling pathway often acts in binary conjunction with a variety of other pathways to produce complex patterning. This patterning follows while involving little of the detailed biochemistry of either of the two pathways involved. The patterns arise spontaneously from a state of zero pattern activation upon achieving a specified (epithelial) sphere radius. Gastrulation follows from the simplest solution, and assuming a simplest form for the coupling of the Gauss and Mean curvatures to the morphogens. Numerical solutions are presented, and predictions of the model are discussed.
- Publication:
-
Physica A Statistical Mechanics and its Applications
- Pub Date:
- August 2004
- DOI:
- 10.1016/j.physa.2004.04.047
- arXiv:
- arXiv:physics/0308030
- Bibcode:
- 2004PhyA..339..531C
- Keywords:
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- Animal development;
- Pattern formation;
- Signaling pathways;
- Wnt;
- Biological Physics;
- Subcellular Processes
- E-Print:
- 30 pages, 5 figures