Limited Slowdown of Endocrine-Disruptor Diffusion in Confined Fluid Lipid Membranes
Abstract
Self-diffusion rates of lipids and trapped bisphenol A (BPA) are determined in various sizes of confined but fluid membranes by high-field-gradient NMR at 600MHz. Micelles and vesicles of 3- to 400-nm diameters are used as model membranes to get an insight into the molecular diffusion in such soft environments. The slowdown of BPA and lipid motions is leveled off in 100- and 400-nm vesicles, although the hydrodynamic continuum model gives the aggregate motion slowed inversely to the aggregate size. Instead, the limited motion is related to the intra-membrane fluidity.
- Publication:
-
Physical Review Letters
- Pub Date:
- December 2004
- DOI:
- 10.1103/PhysRevLett.93.248101
- Bibcode:
- 2004PhRvL..93x8101O
- Keywords:
-
- 87.15.Vv;
- 82.56.Lz;
- 87.64.Hd;
- Diffusion;
- Diffusion;
- EPR and NMR spectroscopy