Programmed Cell Death Protein 4 (PDCD4) Acts As a Tumor Suppressor in Neuroendocrine Tumor Cells
Abstract
PDCD4 is a new tumor suppressor gene. In the current study, we show that overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation. This is most likely caused by a PDCD4-induced downregulation of carbonic anhydrase type II which catalyzes the production of bicarbonate, a fundamental substrate for many cellular pathways.
- Publication:
-
Annals of the New York Academy of Sciences
- Pub Date:
- April 2004
- DOI:
- 10.1196/annals.1294.024
- Bibcode:
- 2004NYASA1014..220G