The early activity of the Sabatini Volcanic District (SVD; central Italy) was characterised by highly explosive eruptions that produced widespread subplinian and plinian fall deposits. In this study, four major eruptive units—informally named as units A, B, C and D—were recognised in the 514-449 ka age interval. In particular, unit D was emplaced during the early phase of the 449 ka Tufo Rosso a Scorie Nere pyroclastic flow-forming eruption, the most important event in the whole SVD activity history. Estimates of relevant eruptive parameters indicate tephra fall volumes up to 4 km 3 for individual units, peak eruption column heights in the range of 14-29 km and corresponding mass eruption rates of 7.8×10 6-1.3×10 8 kg/s. Isopach and isopleth maps of fallout deposits—as well as the distribution of the proximal lag-breccia of the Tufo Rosso a Scorie Nere—consistently indicate a common vent area, which does not correspond to any volcanic centre identified up to now in the SVD. This was located along NE-SW-trending tectonic lineaments that also controlled the location of the other major volcanic centres of the SVD. The characterisation by means of field aspects, grain size, componentry and density and chemical composition of juvenile clasts, renders the studied fall deposits as valuable stratigraphic markers for the SVD and well beyond it. In fact, their wide areal dispersals toward the E and SE may allow correlations on a regional scale for the Quaternary successions of intermountain basins of the Central Apennine and the Adriatic Sea basin successions. Finally, the correct identification of distal tephra from plinian and co-ignimbrite plumes and their attribution to specific explosive eruptions of the SVD and the other volcanic districts of the Roman Province—rather than to local intra-Apennine centres—provides crucial implications for geodynamic reconstructions.