An LEA group 3 family member is involved in survival of C. elegans during exposure to stress
Abstract
In order to establish a functional role for late embryogenesis abundant (LEA) proteins in response to stress conditions in Caenorhabditis elegans, we silenced the expression of an LEA ( Ce-lea-1) gene and determined the survival of worms under stress conditions. Ce-lea-1 transcription was induced during dehydration of C. elegans dauer juveniles. Following partial silencing of Ce-lea-1 transcription, we demonstrated a specific and significant reduction in worm survival during induction of desiccation, osmotic and heat stress. Together, these results establish a functional role for Ce-lea-1 in stress survival of C. elegans and suggest that Ce-lea-1 may function as a component that is common to the responses to the examined stress conditions.
- Publication:
-
FEBS Letters
- Pub Date:
- January 2004
- DOI:
- 10.1016/j.febslet.2004.09.049
- Bibcode:
- 2004FEBSL.577...21G
- Keywords:
-
- Ce-lea-1;
- Ce-lin-53;
- Ce-unc-120;
- Desiccation stress;
- Heat stress;
- Osmotic stress;
- DJ;
- dauer juveniles;
- L1;
- first-stage larva;
- L4;
- fourth-stage larva;
- LEA;
- late embryogenesis abundant;
- RH;
- relative humidity;
- RNAi;
- RNA interference