Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3β

The first two crystal structures of binary complexes of full-length glycogen synthase kinase 3β with the ATP analogues hydrolysate ADP and AMPPNP are described. Although several other crystal structures of the enzyme have already been reported, none of them contain ATP analogues. The structures of these binary complexes reveal detailed features of nucleotide recognition by GSK3β and may have useful implications in the design of drug candidates against Alzheimer's disease.