Anthropic reasoning often begins with the premise that we should expect to find ourselves typical among all intelligent observers. However, in the infinite universe predicted by inflation, there are some civilizations which have spread across their galaxies and contain huge numbers of individuals. Unless the proportion of such large civilizations is unreasonably tiny, most observers belong to them. Thus anthropic reasoning predicts that we should find ourselves in such a large civilization, while in fact we do not. There must be an important flaw in our understanding of the structure of the universe and the range of development of civilizations, or in the process of anthropic reasoning.