Predominant Autoantibody Production by Early Human B Cell Precursors
Abstract
During B lymphocyte development, antibodies are assembled by random gene segment reassortment to produce a vast number of specificities. A potential disadvantage of this process is that some of the antibodies produced are self-reactive. We determined the prevalence of self-reactive antibody formation and its regulation in human B cells. A majority (55 to 75%) of all antibodies expressed by early immature B cells displayed self-reactivity, including polyreactive and anti-nuclear specificities. Most of these autoantibodies were removed from the population at two discrete checkpoints during B cell development. Inefficient checkpoint regulation would lead to substantial increases in circulating autoantibodies.
- Publication:
-
Science
- Pub Date:
- September 2003
- DOI:
- 10.1126/science.1086907
- Bibcode:
- 2003Sci...301.1374W
- Keywords:
-
- IMMUNOLOGY