The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives
Abstract
We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- May 2003
- DOI:
- 10.1073/pnas.1031527100
- Bibcode:
- 2003PNAS..100.6104P
- Keywords:
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- Medical Sciences