Bioinorganic Chemistry Special Feature: The organometallic active site of [Fe]hydrogenase: Models and entatic states
Abstract
The simple organometallic, (μ-S2)Fe2(CO)6, serves as a precursor to synthetic analogues of the chemically rudimentary iron-only hydrogenase enzyme active site. The fundamental properties of the (μ-SCH2CH2CH2S)[Fe(CO)3]2 compound, including structural mobility and regioselectivity in cyanide/carbon monoxide substitution reactions, relate to the enzyme active site in the form of transition-state structures along reaction paths rather than ground-state structures. Even in the absence of protein-based active-site organization, the ground-state structural model complexes are shown to serve as hydrogenase enzyme reaction models, H2 uptake and H2 production, with the input of photo- or electrochemical energy, respectively.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- April 2003
- DOI:
- 10.1073/pnas.0536955100
- Bibcode:
- 2003PNAS..100.3683D
- Keywords:
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- Bioinorganic Chemistry Special Feature