Optimal ion channel clustering for intracellular calcium signaling
Abstract
Ion channels and receptors in the cell membranes and internal membranes are often distributed in discrete clusters. One particularly well-studied example is the distribution of inositol 1,4,5-triphosphate receptors in the plasma membrane that controls the flux of Ca2+ from the endoplasmic reticulum into the cytosol. By using mathematical modeling, we show that channel clustering can enhance the cell's Ca2+ signaling capability. Furthermore, we predict optimal signaling cellular capability at cluster sizes and distances that agree with experimentally found values in Xenopus oocyte. channel dynamics | Markov process | noiseAbbreviations: ER, endoplasmic reticulum IP3, inositol 1,4,5-triphosphate IP3R, IP3 receptor [Ca2+], Ca2+ concentration
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- January 2003
- DOI:
- 10.1073/pnas.0236032100
- Bibcode:
- 2003PNAS..100..506S
- Keywords:
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- Biophysics