We present high-resolution radio maps of Uranus, made from data collected in 1994 at wavelengths of 2 and 6 cm, which show large-scale changes occurring deep and rapidly in the troposphere. Brightness features in these maps are significantly different from those observed throughout the 1980's. These differences are not due to the changing viewing geometry, but result from atmospheric changes in the 5 to 50 bar region. All the observations show strong latitudinal variations in absorber abundance and/or temperature, causing the South Pole to appear brighter than lower latitudes. The transition between bright pole and darker latitudes is always near -45°, but between 1989 and 1994 the contrast between the regions increased significantly. This suggests that the large-scale circulation in the upper 50 bars of the uranian Southern Hemisphere changed. Older, disk-averaged microwave observations have suggested that seasonal variability occurs, but these new maps are the first to provide detailed timing and location information which can be used to test dynamical models.