The Danger Model: A Renewed Sense of Self
Abstract
For over 50 years immunologists have based their thoughts, experiments, and clinical treatments on the idea that the immune system functions by making a distinction between self and nonself. Although this paradigm has often served us well, years of detailed examination have revealed a number of inherent problems. This Viewpoint outlines a model of immunity based on the idea that the immune system is more concerned with entities that do damage than with those that are foreign.
- Publication:
-
Science
- Pub Date:
- April 2002
- DOI:
- 10.1126/science.1071059
- Bibcode:
- 2002Sci...296..301M
- Keywords:
-
- IMMUNOLOGY