APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
Abstract
Early embryonic cells in Caenorhabditis elegans embryos interact through a signaling pathway closely related to the Notch signaling pathway in Drosophila and vertebrates.Components of this pathway include a ligand, receptor, the presenilin proteins, and a novel protein, APH-2, that is related to the Nicastrin protein in humans. Here we identify the aph-1 gene as a new component of the Notch pathway in Caenorhabditis elegans. aph-1 is predicted to encode a novel, highly conserved multipass membrane protein. We show that aph-1 and the presenilin genes share a similar function in that they are both required for proper cell-surface localization of APH-2/Nicastrin.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- January 2002
- DOI:
- 10.1073/pnas.022523499
- Bibcode:
- 2002PNAS...99..775G
- Keywords:
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- Developmental Biology