QSAR of benzene derivatives: comparison of classical descriptors, quantum theoretic parameters and flip regression, exemplified by phenylalkylamine hallucinogens
Abstract
A physical model of electronic effects in the QSAR of benzene derivatives, together with a regression technique for finding predictive equations, is presented. The model is simple, based on the quantum theoretic description of the benzene molecule, and accounts for the variance in activity of hallucinogenic phenylalkylamines as well as a classical description in terms of electronic (atomic charge, orbital energy), hydrophobic (Hansch π) and steric (substituent volume) terms. The new model involves the energies of four πlike near frontier orbitals and the orientations of their nodes. It is less affected by colinearity than the classical approach. This model more than any other illustrates the essential wave mechanical nature of the interaction of a drug with its receptor, as the πlike orbitals involved are standing waves of probability of finding an electron in a given location in the field of the atomic nuclei, and have no classical counterpart.
 Publication:

Journal of ComputerAided Molecular Design
 Pub Date:
 August 2002
 DOI:
 10.1023/A:1021966231380
 Bibcode:
 2002JCAMD..16..611C
 Keywords:

 benzene;
 FOPA;
 hallucinogen;
 phenylalkylamine;
 QSAR;
 quantum;
 regression;
 symmetry