Observations of emissivity features of 10 Hygiea have been made for the first time in the relatively unexplored thermal-infrared wavelength region with the ISO (Infrared Space Observatory) satellite. Spectrophotomer (PHT-S) and short wavelength spectrometer (SWS) spectra of 10 Hygiea, obtained at 5.8-11.6 and 7-45 μm, respectively, are presented. In order to remove the thermal emission continuum, an advanced thermo-physical model has been applied to the observational data. To better interpret the spectral features above the thermal emission continuum, we compared the ISO observations with laboratory spectra available in the literature. Several laboratory experiments on minerals and meteorites have been performed to complete the analysis and to study the spectral behavior at various grain sizes. A possible spectral similarity with CO carbonaceous chondrites at small grain size is demonstrated.