Distribution of the second virial coefficients of globular proteins
Abstract
George and Wilson (Acta. Crystallogr. D, 50 (1994) 361) looked at the distribution of values of the second virial coefficient of globular proteins, under the conditions at which they crystallise. They found the values to lie within a fairly narrow range. We have defined a simple model of a generic globular protein. We then generate a set of proteins by picking values for the parameters of the model from a probability distribution. At fixed solubility, this set of proteins is found to have values of the second virial coefficient that fall within a fairly narrow range. The shape of the probability distribution of the second virial coefficient is Gaussian because the second virial coefficient is a sum of contributions from different patches on the protein surface.
 Publication:

EPL (Europhysics Letters)
 Pub Date:
 December 2002
 DOI:
 10.1209/epl/i2002003081
 arXiv:
 arXiv:condmat/0207293
 Bibcode:
 2002EL.....60..938S
 Keywords:

 87.14.Ee;
 87.15.Nn;
 Proteins;
 Properties of solutions;
 aggregation and crystallization of macromolecules;
 Condensed Matter  Soft Condensed Matter;
 Quantitative Biology  Biomolecules
 EPrint:
 5 pages, including 3 figures