Messenger RNA Degradation: Beginning at the End
Abstract
The mechanisms responsible for mRNA decay in mammalian cells, and how specific sequence elements accelerate decay, are unknown. Recent work indicates that 'ARE' instability elements recruit the exosome to promote rapid 3'-to-5' degradation of the mRNA.
- Publication:
-
Current Biology
- Pub Date:
- April 2002
- DOI:
- 10.1016/S0960-9822(02)00802-3
- Bibcode:
- 2002CBio...12.R285V