KLF6, a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer
Abstract
Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor of unknown function. Here, we show that the KLF6 gene is mutated in a subset of human prostate cancer. Loss-of-heterozygosity analysis revealed that one KLF6 allele is deleted in 77% (17 of 22) of primary prostate tumors. Sequence analysis of the retained KLF6 allele revealed mutations in 71% of these tumors. Functional studies confirm that whereas wild-type KLF6 up-regulates p21 (WAF1/CIP1) in a p53-independent manner and significantly reduces cell proliferation, tumor-derived KLF6 mutants do not. Our data suggest that KLF6 is a tumor suppressor gene involved in human prostate cancer.
- Publication:
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Science
- Pub Date:
- December 2001
- DOI:
- 10.1126/science.1066326
- Bibcode:
- 2001Sci...294.2563N
- Keywords:
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- MEDICINE