From the Cover: Regulation of NMDA receptors by cyclin-dependent kinase-5
Abstract
Members of the N-methyl-D-aspartate (NMDA) class of glutamate receptors (NMDARs) are critical for development, synaptic transmission, learning and memory; they are targets of pathological disorders in the central nervous system. NMDARs are phosphorylated by both serine/threonine and tyrosine kinases. Here, we demonstrate that cyclin dependent kinase-5 (Cdk5) associates with and phosphorylates NR2A subunits at Ser-1232 in vitro and in intact cells. Moreover, we show that roscovitine, a selective Cdk5 inhibitor, blocks both long-term potentiation induction and NMDA-evoked currents in rat CA1 hippocampal neurons. These results suggest that Cdk5 plays a key role in synaptic transmission and plasticity through its up-regulation of NMDARs.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- October 2001
- DOI:
- 10.1073/pnas.211428098
- Bibcode:
- 2001PNAS...9812742L
- Keywords:
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- From the Cover