ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma
Abstract
DPC4 is known to mediate signals initiated by type β transforming growth factor (TGFβ) as well as by other TGFβ superfamily ligands such as activin and BMP (bone morphogenic proteins), but mutational surveys of such non-TGFβ receptors have been negative to date. Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer. ACVR1B has not been described previously as a mutated tumor-suppressor gene.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- March 2001
- DOI:
- 10.1073/pnas.051484398
- Bibcode:
- 2001PNAS...98.3254S
- Keywords:
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- Genetics