Genetic disruption of PPARδ decreases the tumorigenicity of human colon cancer cells
Abstract
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that have been implicated in a variety of biologic processes. The PPARδ isotype was recently proposed as a downstream target of the adenomatous polyposis coli (APC)/β-catenin pathway in colorectal carcinogenesis. To evaluate its role in tumorigenesis, a PPARδ null cell line was created by targeted homologous recombination. When inoculated as xenografts in nude mice, PPARδ -/- cells exhibited a decreased ability to form tumors compared with PPARδ +/- and wild-type controls. These data suggest that suppression of PPARδ expression contributes to the growth-inhibitory effects of the APC tumor suppressor.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- February 2001
- DOI:
- 10.1073/pnas.051630998
- Bibcode:
- 2001PNAS...98.2598P
- Keywords:
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- Medical Sciences