Stochastic spreading of intracellular Ca2+ release
Abstract
We study the spreading of calcium-induced calcium release with the stochastic DeYoung-Keizer-model of the inositol 1,4,5-trisphosphate receptor channel. The model shows a transition from isolated release events to steadily propagating waves with increasing IP3 concentration. A state-stochastic backfiring-was found in the regime of steady propagation. The model can be reduced by an adiabatic elimination of the partial differential equation for the Ca2+ concentration to a lattice of stochastic channel clusters.
- Publication:
-
Physical Review E
- Pub Date:
- August 2000
- DOI:
- 10.1103/PhysRevE.62.2636
- Bibcode:
- 2000PhRvE..62.2636F
- Keywords:
-
- 87.16.Xa;
- 05.40.-a;
- 82.20.Mj;
- Signal transduction;
- Fluctuation phenomena random processes noise and Brownian motion