The DNA damage response: putting checkpoints in perspective
Abstract
The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks.
- Publication:
-
Nature
- Pub Date:
- November 2000
- DOI:
- 10.1038/35044005
- Bibcode:
- 2000Natur.408..433Z