Observations of the last decade testify that the characteristics of the deep thermohaline circulation in the Eastern Mediterranean Sea have changed thoroughly. The source of the most dense waters of the basin has moved from the Adriatic to the Aegean Sea. This new source has proved to be very efficient since the estimated formation rate for the period 1989-95 was more than 1 Sv, about three times more than the dense water formation rate of the Adriatic Sea. These new waters with hydrological characteristics, that are warmer and more saline, have replaced almost 20% of the older deep waters of the basin, and have uplifted the deep isopycnals by about 500 m. This major event can be attributed to important meteorological anomalies in the Eastern Mediterranean and to changes of circulation patterns. The extended dry period of 1988-93 and the exceptionally cold winters of 1987 and 1992-93 created favorable conditions for increased formation of dense water in the Aegean. Furthermore, changes in the circulation patterns in the intermediate water range (Levantine Intermediate Water LIW and Cretan Intermediate Water), themselves possibly linked to meteorological anomalies, appear to have played an important role in the redistribution of salt. As a result of an interruption to exchanges between the Ionian and Levantine Basin, the salinities in the latter started to rise, high salinity waters were diverted into the Aegean [ Malanotte-Rizzoli, P., Manca, B. B., Ribera dAcala, M., & Theocharis, A. (1998). The Eastern Mediterranean in the 80s and in the 90s: the big transition emerged from the POEM-BC observational evidence. Rapport du Commission International de la Mer Medittanee, 35, 174-175] and the westward transport of LIW was reduced. An additional effect of the deep water discharge from the Aegean and the resulting uplifting of mid-depth waters was to lower salinities in the LIW layer. This effect is most strongly felt in the Ionian Sea. A 3-D primitive equation numerical model for the Eastern Mediterranean with a 20 km grid size is used to simulate the observed changes and understand the basic mechanisms which caused them. Under appropriate atmospheric forcing the model successfully reproduces the main characteristics of the transient. These results indicate that the observed changes can be, at least partially, explained as a response of the Eastern Mediterranean, and more specifically of the Aegean, to atmospheric forcing variability.