Synexpression groups in eukaryotes
Abstract
In 1960, Jacob and Monod described the bacterial operon, a cluster of functionally interacting genes whose expression is tightly coordinated. Global expression analysis has shown that the highly coordinate expression of genes functioning in common processes is also a widespread phenomenon in eukaryotes. These sets of co-regulated genes, or `synexpression groups', show a striking parallel to the operon, and may be a key determinant facilitating evolutionary change leading to animal diversity.
- Publication:
-
Nature
- Pub Date:
- December 1999
- DOI:
- 10.1038/990025
- Bibcode:
- 1999Natur.402..483N