A semi-molten mixture of hexadecyltributylphosphonium bromide and potassium fluoride in the synthesis of organofluorine compounds
Abstract
A facile and effective reagent system comprising of a semi-molten mixture of hexadecyltributylphosphonium bromide and potassium fluoride has been developed and its scope has been investigated in nucleophilic fluoride exchange with various organohalides. This simple and convenient reagent system provides organofluorine compounds in high yields even with haloesters in which fluoride catalysed elimination is also feasible.
- Publication:
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Journal of Fluorine Chemistry
- Pub Date:
- January 1999
- DOI:
- 10.1016/S0022-1139(99)00121-9
- Bibcode:
- 1999JFluC..99..115B
- Keywords:
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- Semi-molten mixture;
- Hexadecyltributylphosphonium bromide;
- Organofluorine compounds