Evidence for Functional and Physical Association between Caenorhabditis elegans SEL-10, a Cdc4p-Related Protein, and SEL-12 Presenilin
Abstract
Mutations in either of two human presenilin genes (PS1 and PS2) cause Alzheimer's disease. Here we describe genetic and physical interactions between Caenorhabditis elegans SEL-10, a member of the Cdc4p family of proteins, and SEL-12, a C. elegans presenilin. We show that loss of sel-10 activity can suppress the egg-laying defective phenotype associated with reducing sel-12 activity, and that SEL-10 can physically complex with SEL-12. Proteins of the Cdc4p family have been shown to target proteins for ubiquitin-mediated turnover. The functional and physical interaction between sel-10 and sel-12 therefore offers an approach to understanding how presenilin levels are normally regulated.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- December 1998
- DOI:
- 10.1073/pnas.95.26.15787
- Bibcode:
- 1998PNAS...9515787W