Two-State Models of Protein Folding Kinetics
Abstract
The folding of some proteins appears to be a two-state kinetic process. A two-state kinetic model is justified if protein molecules rapidly equilibrate between different unfolded conformations prior to complete folding. Here I show that this rapid equilibration is a natural consequence of reasonable assumptions about reaction rate constants and folding thermodynamics.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- January 1997
- DOI:
- 10.1073/pnas.94.1.148
- Bibcode:
- 1997PNAS...94..148Z