Macro- and microbeam analysis of lithium by the Li(p,α)α7i(p,α)α reaction, and STIM imaging of white blood cells
Two different experimental arrangements for lithium analysis through the 7Li(p,α)α reaction are described. The minimum detection limit (MDL) was 300 pg/cm 2 for an integrated charge of 60 μC for a macrobeam set-up optimized for high-current applications. For a Nuclear Microprobe (NMP) arrangement the MDL was 6 ng/cm 2 for an integrated charge of 1 μC in a set-up with large solid angles. One type of blood cells, lymphocytes, was analyzed at the NMP in the context of the treatment of patients with affective disorders ("manic-depressive illness") with lithium. The amount of lithium in the lymphocytes was found to be below the detection limit, i.e. less than 150 fg/cell. Separated lymphocytes were found to be well suited for both STIM and off-axis STIM imaging.