Patterning the Vertebrate Neuraxis
Abstract
Neuraxial patterning is a continuous process that over a protracted period of development. During gastrulation a crude anteroposterior pattern, Detectable by molecular markers, is conferred on the neuroectoderm by singnals from the endomesoderm that are largely inseparable from those of neural induction itself. This coarse-grained pattern is subsequently reinforced and refined by diverse, locally acting mechanisms. Segmentation and long-range signaling from organizing centers are prominent among the emerging principles governing regional pattern.
- Publication:
-
Science
- Pub Date:
- November 1996
- DOI:
- 10.1126/science.274.5290.1109
- Bibcode:
- 1996Sci...274.1109L