The Aging Immune System: Primer and Prospectus
Abstract
Changes in T lymphocyte populations underlie much of the age-related decline in the protective immune response. Aging leads to the replacement of virgin T cells by memory T cells and to the accumulation of cells with signal transduction defects. Studies of antibody gene assembly, accessory cell function, post-thymic T cell development, skewed selection of T cell receptor repertoire, and the clinical concomitants of immune senescence will shed new light on the causes and consequences of age-dependent immune failure.
- Publication:
-
Science
- Pub Date:
- July 1996
- DOI:
- 10.1126/science.273.5271.70
- Bibcode:
- 1996Sci...273...70M