Selective Activation of NF-kappaB by Nerve Growth Factor Through the Neurotrophin Receptor p75
Abstract
Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) selectively bind to distinct members of the Trk family of tyrosine kinase receptors, but all three bind with similar affinities to the neurotrophin receptor p75 (p75NTR). The biological significance of neurotrophin binding to p75NTR in cells that also express Trk receptors has been difficult to ascertain. In the absence of TrkA, NGF binding to p75NTR activated the transcription factor nuclear factor kappa B (NF-kappaB) in rat Schwann cells. This activation was not observed in Schwann cells isolated from mice that lacked p75NTR. The effect was selective for NGF; NF-kappaB was not activated by BDNF or NT-3.
- Publication:
-
Science
- Pub Date:
- April 1996
- DOI:
- 10.1126/science.272.5261.542
- Bibcode:
- 1996Sci...272..542C