Channel Behavior in a γ -Aminobytyrate Transporter
Abstract
Current produced by a gamma-aminobutyrate (GABA) transporter stably transfected into a mammalian cell line was observed in cell-attached and excised membrane patches. When GABA was absent, a fraction of the transporters produced cation-permeable channels. When GABA plus Na+ was on either side of the membrane, the majority of transporters produced a high-frequency current noise attributed to the movement of ions in an occluded pore.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- January 1996
- DOI:
- 10.1073/pnas.93.2.723
- Bibcode:
- 1996PNAS...93..723C